The great Chilean discovery to reduce hypertension

The great Chilean discovery to reduce hypertension

A team of Chilean researchers made a discovery that could help mitigate the effects of hypertension.

Hypertension is a chronic disease . It’s an increase in blood pressure in the arteries and it affects almost a third of the Chilean population.

The medical treatment for this condition entails a  daily intake of drugs that inhibit the production or action of angiotensin II. As explained by the co-author Mario Chiong, this a molecule that, “is manufactured through a peptide synthesized in the liver called angiotensinogen and subsequently metabolized to angiotensin I “. 

“Angiotensin II is generated enzymatically from angiotensin I and directly and indirectly increases blood pressure,” said Chiong, who is a researcher at ACCDiS and a Professor at the Faculty of Chemical and Pharmaceutical Sciences of the University of Chile.



Given the above, the ACCDiS researchers approached angiotensin 1-9, which is present in our body. 

The professor explained that “Some time ago we described that angiotensin I could be converted into another peptide than angiotensin II, which is angiotensin 1-9. This peptide was long thought to be inactive. However, we discovered that it has biological activity and, most interestingly, an action completely contrary to angiotensin II “

It should be noted that the finding has been the result of  more than a decade’s work, led by doctors Maria Paz Ocaranza, Jorge Jalil and Luis Michea, who have studied cardiovascular diseases and in particular hypertension and the damage associated with this disease.

In this sense, and thanks to these investigations, two patents have been filed:

“The first one regarding angiotensin 1-9 as cardioprotective, and the second as a new antihypertensive peptide,” explained doctor Sergio Lavandero, director of ACCDiS and member of the research team.

The Team

The team of this project has already carried out the preclinical studies of the molecule to move soon on to clinical trials. This with the aim of pharmacologically arranging angiotensin 1-9.

“What we know is that the drugs that currently lower blood pressure work very well. But even when the pressure is normalized, patients may experience some kind of damage to the organs” Chiong explained.


Only 37% get treated

High blood pressure is a chronic disease that involves an increase in blood pressure in the arteries. In Chile it affects almost a third of the population and increases its prevalence with age, affecting 75% of the elderly of our country. In addition, of all the people who suffer from high blood pressure , 65% are diagnosed and only 37% get treated.


Source: El Mercurio de Chile.

Health Advice. How Can We Triglycerides Be Reduced ?

Health Advice. How Can We Triglycerides Be Reduced ?

One of the first consequences of excess weight is the rise of cholesterol and triglyceride levels, along with an increase in abdominal fat. That is why it is worth asking: How can we reduce the triglycerides?

Chile is one of the countries in Latin America with the highest rate of obesity in its population. According to the latest National Health Survey, 64.5% of the population suffers from excess weight, a figure quite alarming for the future.

The high levels of these lipids bring serious consequences for health, for example:


-Cardiovascular diseases

-Reduction of size of the arteries

-It could even cause death.

Therefore, it’s important to pay attention to your cholesterol levels and particularly the triglycerides. We give you some tips to reduce both, thus avoiding serious consequences for your health.

Increase the intake of dietary fiber

Everything starts with your eating habits, so we recommend you change white bread for wholegrain bread. The more natural and fibrous it is, the better for you. You can also help reduce your triglyceride levels by eating more fruits rich in fiber such as apples, oranges, pears, tangerines and pineapples; and eating vegetables several times a week.

If you do not like fruit or legumes, you can take a spoonful of oatmeal in ½ cup of water on an empty stomach. This will naturally help your bowel movements and give you energy to start the day.


Limits the consumption of sugars and fast food

Many people are still not aware of the harmful effects of a diet high in sugar and  fried foods. It is recommended yo reduce your intake of these foods as much as possible.

Nowadays there is a great variety of sweeteners that can be healthy alternatives to add a sweet touch to your drinks and preparations.


Mind the fats you eat

We know that mayonnaise is a faithful companion, but it is very harmful to your health. So it is better to replace it with more natural fats such as avocado, olive oil or other dressings such as lemon and vinaigrettes. Thus, your meals will be delicious and, above all, healthier.

Physical exercise

30 minutes of walking, biking, walking your dog or going for a walk to the park with family or friends will fill you with good energy. But that’s not all, as physical activity will also help lower triglyceride levels in your body.

Sit down, reflect on your health and take action before it’s too late. Remember that to keep healthy you should not only become aware and self-evaluate, but you should seek professional help as well.

You can also take Cardiosmile which is completely natural, scientifically proven and gives you all the benefits of phytosterols to reduce cholesterol and triglyceride levels much faster.



The Metabolic Syndrome is a set of physical and metabolic alterations that doubles the cardiovascular risk and increases fivefold the risk of developing Diabetes Mellitus. Additionally, it increases the risk of developing fatty liver and biliary lithiasis, among others. In Chile, this syndrome has a high prevalence that increases with age; it is found in 7% of those under 25 years of age but in 56% in those over 65 years of age, according to data from the last National Health Survey.

55% of Chilean adults are sedentary and overweight, two of the main triggers of this condition. To treat it, it is essential to achieve a healthy lifestyle and, thus, prevent heart problems.

Sylvana Freire, Cardiosmile nutritionist, explains that to be diagnosed with Metabolic Syndrome, it is enough to meet three of the following requirements: high presence of abdominal fat, low concentrations of HDL or ‘good’ cholesterol, high levels of triglycerides in the blood, hypertension and elevated blood sugar.




Freire  says: “55% of Chilean adults have the main triggers of the Metabolic Syndrome simultaneously, they are both sedentary and overweight. Therefore, the main objective to treat this condition, and prevent the development of a cardiovascular disease, is to achieve a healthy lifestyle. ” To do so, she recommends following these guidelines:


Decrease the intake of refined carbohydrates and alcohol consumption, and replace it with a diet rich in vegetables and healthy fats.

Thus is increased the consumption of phytosterols which in turn reduce cholesterol levels and the risk of cardiovascular diseases.



A 5% decrease in body weight causes a decrease in blood sugar, triglycerides and the risk of developing Diabetes.

Always maintain a balanced diet, complementing it with an exercise routine according to your possibilities.



Exercise diminishes cardiovascular morbidity and mortality through the reduction of LDL cholesterol, blood pressure and an increase in HDL cholesterol. 




One in four Chileans has high levels of bad cholesterol or LDL, which increases the risk of cardiovascular diseases, the first cause of death in our country. The positive thing is that, according to the WHO, 80% can be avoided through adequate prevention.

That is why, within the framework of the Month of the Heart, the traveling clinic called “Mobile Heart” will be traveling through several communes of Santiago to carry out free measurements of cholesterol, blood sugar, blood pressure, electrocardiograms and medical consultations in the field.

This activity is organized by the Foundation of the Chilean Society of Cardiology and Cardiovascular Surgery (Sochicar), with the participation of Cardiosmile, a unique solution in the world,  clinically proven to naturally reduce cholesterol and triglycerides.

“This type of activity encourages people to have a preventive culture. They are encouraged to be informed about the conditions they may suffer and how to help the heart with good nutrition.Thus, we want to contribute to the development of a society aware of its health and educated on how to prevent cardiovascular problems, by decreasing the high levels of cholesterol in the blood that people have in our country, and the number of deaths caused by absence of treatment “says Gonzalo Vega, biochemist and co-creator of Cardiosmile.




  • Tuesday, August 1, from 8:30 a.m. to 2:30 p.m.: Plaza de la Aviación, Providencia.
  • Wednesday, August 2, from 8:30 a.m. to 2:30 p.m.: Plaza Monumento, Maipú.
  • Thursday, August 3, from 8:30 a.m. to 2:30 p.m.: El Llano Sector (in front of Supermarket Jumbo), San Miguel.
  • Friday, August 4, from 8:30 a.m. to 2:30 p.m.: Municipality of La Granja


Reference Link: Datéate 



JULY 17, 2017


According to data from the last National Health Survey, in Chile there is a high prevalence of Metabolic Syndrome. Especially in people who are becoming elderly,  while 56% of those over 65 have this condition, it is present in only 7% of those under 25 years of age.

The numbers are worrisome, because it is a set of physical alterations or pathologies that increase the probability of generating coronary diseases and cerebrovascular accidents at twice the risk, and five times the risk of developing Type II Diabetes. In addition, it increases the danger of fatty liver and biliary lithiasis, among other conditions.

For this reason, the Metabolic Syndrome should be taken seriously. Nutritionist Paulina Hernández, head of the Living Well Program of Sodexo, says that to identify it, different criteria are analyzed:

  • The waist index (over 90 centimeters in men and 80 in women)
  • Blood triglycerides (above 150 mg/dl)
  • HDL or “good” cholesterol (low 40 mg/dl in men and under 50 mg/dl in women)
  • Blood pressure (about 130/85 mmHg or hypertension)
  • Fasting blood glucose (above 100 mg/dl or with diagnosed Diabetes).

If three of these “requirements” are present, the person is diagnosed with Metabolic Syndrome.


Paulina Hernández says that, in addition to age and hormonal alterations, genetic predisposition is one of the variables that can increase the chances of developing the aforementioned conditions and therefore the Metabolic Syndrome. 

Thus, there are certain risk factors that are not very avoidable. However, she emphasizes that there are others that are manageable by people, since they are mainly related to lifestyle such as smoking, a sedentary lifestyle, obesity and even abuse of medication or stress.

Sylvana Freire, Cardiosmile nutritionist, warns that the point is that “55% of Chilean adults have the main triggers of Metabolic Syndrome simultaneously, namely being sedentary and overweight.”

The expert points out that the main thing to avoid and/or treat this condition, and thus prevent its negative effects on health, is to address the conditions that confirm the syndrome, which in some cases may involve the use of drugs, but, fundamentally, the best weapon is “to achieve a healthy lifestyle,”.

For this purpose, obviously, one of the first tips of the professional is to avoid and/or quit smoking.

She also stresses that weight should be controlled as any excess of it or obesity. It has been proven that decreasing 5% of your body weight leads to a lowering of blood sugar, triglycerides and a lessening of  the risk of developing Diabetes Mellitus .

Another important preventive action is doing regular physical activity, always considering the interests and possibilities of each person. Exercise lowers cardiovascular morbidity and mortality through the reduction of LDL and increase of HDL cholesterol, and decreases blood pressure.




Another of the primary preventive actions of healthy lifestyle habits is to follow a healthy and balanced diet. The intake of refined carbohydrates and alcohol consumption should be reduced, while the consumption of healthy vegetables and fats should be increased.

According to the nutritionist, this increases the consumption of phytosterols, a natural compound of vegetable origin that decreases the absorption of cholesterol, contributing to the reduction of harmful levels and decreasing the risk of cardiovascular diseases.

Paulina Hernández adds that a fundamental aspect of a healthy diet is that it is diverse. “We must vary in terms of the foods consumed, privileging those low in fat and sugar,” she says.

You should eat every three hours, which means eating every day breakfast, lunch, dinner, snack and dinner. Maintaining and complying with meal times on a daily basis is another key to avoiding Metabolic Syndrome and with it all the negative health effects that this entails.


A healthy diet is based on eating four times a day, keeping a regular schedule. Bur a healthy diet should also be a varied diet.  Here are some tips:




Oils provide vitamins and fatty acids that the body can not synthesize and they are very beneficial for your health. “You have to consume them in moderation because they are rich in calories. They may be replaced by avocado, olives or nuts,” she says. Animal fats should be avoided. 




The nutrionist emphasizes that an appropriate amount of fluid keeps the body hydrated, prevents constipation and cavities. It has been said that it decreases the risk of bladder and colon cancer, and the formation of kidney stones. Natural water can be replaced by mineral water or the water used to cook fruits, sugar-free infusions or sugar-free jellies.




They contain antioxidants such as vitamins and minerals, as well as fiber and water. These help keep the body in perfect condition.



These dairy products can be milk, yogurt or soft cheese. These products provide calcium and vitamin D, necessary to maintain bone health, and promote the burning of abdominal fat.



Eat them as a main course, accompanied by rice or noodles, and without meats or sausages. Eat fish at least twice a week: fresh or canned in water. Fish is a food that provides omega 3 fatty acids, which help prevent cardiovascular disease and stimulate the proper functioning of the nervous system.

55% of Chilean adults are both overweight and sedentary simultaneously.

Reference link: Diario el Sur – Concepción



How can we identify physical risks in children? Physical tests help us to know the health status of children. An example is the so-called “20-meter test” or “round-trip test”, a simple test that consists in making children run that distance.




The conclusion reached by the analysis of seven studies on the subject is that it is indeed a useful tool to detect the risk of developing a cardiovascular problem in adulthood.

This includes data on more than 9 thousand children and adolescents between 8 and 19 years old, from 14 different countries. 

Jonatan Ruiz, researcher of the Physical Education and Sports Department, coordinator of the study, states:  “These tests are used in schools. They offer us information of enormous value about the state of children’s health “

Actually, this test is used in most schools in Spain, as well as in many European countries and in the Americas (including Chile), to measure the aerobic capacity of minors in Physical Education classes.

According to the analysis, the risk of suffering cardiovascular diseases in the future, in the case of children, ranged from minors with 6% to others with 39%. Among girls, the risk varied from those with 6% risk, to others with 86%.

“Below the recommended fitness levels we must raise a red flag to keep us on the alert,” says Ruiz.




According to doctor Bernardita Lopetegui, child cardiologist and assistant professor of the Department of Pediatrics of the Faculty of Medicine of the University of  Chile, “If used alone as a diagnostic at the beginning of the school year, it will reflect the condition of the children at that time. But if you compare it with a new evaluation after a few months of training, that would be useful. “

This would make it possible to identify the children with worse physical performance and to put in place an intervention to improve their physical condition.

Otherwise, “if a child performed poorly and maintains this condition, as an adult he/she will have very high risk of cardiovascular problems. It’s about protecting the health of adults from childhood. “

For Ruiz, it would be ideal to establish international standards related to the measurement of infant aerobic capacity, similar to those used to determine overweight or obesity, in order to favour the prevention of problems.

Source: El Mercurio.



The risks of constant smoking are numerous. Smokers could increase their risk of clogging the arteries by weakening a gene that otherwise protects those important blood vessels, US researchers said on Monday.


It is public knowledge that many people are not able to get away from their cigarette packs, reaching the point where even one pack is not enough. This is how they slowly fall into a vicious circle that forces them to smoke even more.

Surely you know a case in your social cricle and you know what we are talking about. Addiction produced by nicotine causes many people to spend much more money than they should. It is scientifically proven that our lungs take almost 6 months to eliminate these substances. But luckily for us this is not the study related to that subject.


The findings point to a genetic explanation about how smoking can lead to plaque buildup that hardens the arteries and causes heart disease, according to a report published in the Circulation journal.

“This has been one of the first major steps towards solving the complex puzzle of genetic-environmental interactions that lead to coronary heart disease,” said study co-author Danish Saleheen, an assistant professor of Biostatistics and Epidemiology at the Perelm School of MedicineUniversity of Pennsylvania.

Researchers gathered genetic data from more than 140,000 people, handled in more than two dozen previous studies, with a particular focus on regions of the genome that had previously been associated with a high risk of plaque buildup in the arteries of the heart.


“A change in a single ‘letter’ of DNA on chromosome 15, near the gene that exposes an enzyme (ADAMTS7) produced in blood vessels, was associated with a 12 percent reduction in cardiac risk in non-smokers. ” 

“However, smokers with the same variation had only five percent less risk of coronary heart disease. Reducing by more than half the protective effect of this genetic variation”.

Follow-up scientific studies showed that in the cells lining the arteries of the human heart, the production of the enzyme ADAMTS7 decreased significantly when cells contained this single-letter variant of DNA.